Homocysteine—The Hormone Disruptor You’re Not Being Told About
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Homocysteine: The Hormone Disruptor No One Talks About
You hear about inflammation constantly. Gut health. Adrenals. Stress.
But there’s another marker flying under the radar—homocysteine—and if you’re dealing with hormonal acne, mood swings, infertility, or fatigue despite doing “everything right,” this could be your missing piece.
Let’s talk about it.
What Is Homocysteine?
Homocysteine is an amino acid produced when your body breaks down methionine (an essential amino acid from protein).
Normally, your body clears it efficiently. But when it builds up? It becomes a hormone-disrupting, inflammation-driving, mood-wrecking mess.
High homocysteine has been linked to:
Hormonal imbalances (especially estrogen & progesterone)
Mood disorders like anxiety and depression
Brain fog and chronic fatigue
Cardiovascular risks
Pregnancy complications and infertility
Skin issues (hello, hormonal acne)
Yet most standard blood panels don’t include it.
What MTHFR Has to Do With It
Here’s where it gets juicy:
Around 30–40% of people have a mutation in the MTHFR gene. This gene helps your body recycle homocysteine.
When it doesn’t work properly, homocysteine builds up—and can quietly sabotage your health.
But even if you don’t have the mutation (I didn’t), you can still have elevated levels if your methylation is off or your body is missing key nutrients.
My Story: Hormonal Acne, Normal Labs, and a Wake-Up Call
I spent years trying to “fix” my skin.
I cleaned up my diet. Switched to non-toxic skincare. Tried every hormone-balancing supplement under the sun.
Still? My skin flared up. My energy dipped. And every doctor said:
“Your labs look fine.”
Spoiler: they weren’t looking at homocysteine.
I decided to test it myself—and boom. My levels were elevated.
Even without the MTHFR mutation, my body was apparently struggling to clear it. And it was showing up as acne, fatigue, and irritability.
How I Lowered My Homocysteine Naturally
No prescriptions. No wild protocols. Just consistent, intentional health optimization.
What worked for me:
Strategy | What I Did |
Methylated B Vitamins | Took B12 (methylcobalamin), B6 (P5P), and methylfolate daily |
Choline Support | Ate pasture-raised egg yolks, liver, salmon |
Minerals | Supplemented magnesium, zinc; shilajit, added good quality salt to water |
Daily Detox | Used chlorella, cilantro, cruciferous veggies... plus binders, saunas... and more! full detox breakdown coming soon |
Nervous System Care | Prioritized deep sleep, stress regulation, nervous system healing |
Low-Tox Living | Swapped to non-toxic skincare, home cleaning, and filtered water |
After about 8 months? I re-tested.
➡️ My homocysteine was back in range. My skin is better than it's ever been. My mood felt balanced. I felt like me again.
Signs You Might Have Elevated Homocysteine
Here’s what to watch for:
Hormonal acne
Mood swings, anxiety, or depression
Low B12 or folate despite supplementing
Fatigue, brain fog, or irritability
History of miscarriage or fertility challenges
Circulation issues, cold hands/feet, palpitations
If you’ve been told “everything looks fine” but you don’t feel fine? This could be it.
What Test to Ask For
Ask your practitioner for a fasting plasma homocysteine test. It’s a simple blood draw but not usually included in routine panels.
💡 Bonus: Pair it with MTHFR testing (saliva, blood).
Final Word: Don’t Accept “Fine”
You’re not crazy. You’re not lazy. You’re not “just getting older.”
If you’re doing all the things and still feeling off—this might be the clue you need.
Balancing homocysteine and hormones (as a result) helped me:
Clear my skin
Stabilize my mood
Boost my energy
Deepen my connection to my body
And I believe it can help you too.
You deserve more than “everything looks fine.”You deserve to feel better than ever.
Let’s start with homocysteine.
🖤 — Aneta
